Michael Weller Selected Research

Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

1/2023	Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma.
10/2020	Immunocytokines are a promising immunotherapeutic approach against glioblastoma.
1/2018	Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.
11/2009	SC68896, a novel small molecule proteasome inhibitor, exerts antiglioma activity in vitro and in vivo.
7/2006	Regulation of pulmonary Pseudomonas aeruginosa infection by the transcriptional repressor Gfi1.
5/2003	Muscle fibres and cultured muscle cells express the B7.1/2-related inducible co-stimulatory molecule, ICOSL: implications for the pathogenesis of inflammatory myopathies.
1/2003	Adenoviral (full-length) Apo2L/TRAIL gene transfer is an ineffective treatment strategy for malignant glioma.
8/2002	Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.
5/2002	Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Michael Weller Research Topics

Disease

294	Neoplasms (Cancer) 05/2024 - 01/2002
269	Glioblastoma (Glioblastoma Multiforme) 05/2024 - 01/2002
232	Glioma (Gliomas) 05/2024 - 01/2002
55	Brain Neoplasms (Brain Tumor) 01/2024 - 05/2002
34	Astrocytoma (Pilocytic Astrocytoma) 05/2024 - 05/2002
22	Meningioma (Meningiomas) 05/2024 - 01/2016
22	Lymphoma (Lymphomas) 04/2024 - 02/2002
22	Neoplasm Metastasis (Metastasis) 01/2023 - 06/2003
18	Oligodendroglioma 05/2024 - 10/2002
15	Hypoxia (Hypoxemia) 01/2024 - 08/2002
13	Necrosis 12/2023 - 05/2003
13	Melanoma (Melanoma, Malignant) 11/2022 - 08/2002
12	Seizures (Absence Seizure) 01/2024 - 08/2005
12	Disease Progression 01/2023 - 09/2002
11	Epilepsy (Aura) 01/2024 - 01/2006
10	Stroke (Strokes) 02/2024 - 12/2009
10	Infections 04/2023 - 01/2003
10	Multiple Sclerosis 01/2019 - 10/2003
7	Thrombocytopenia (Thrombopenia) 01/2023 - 10/2002
7	Breast Neoplasms (Breast Cancer) 01/2023 - 12/2002
7	Fatigue 01/2023 - 07/2015
6	Inflammation (Inflammations) 12/2023 - 11/2003
5	Residual Neoplasm 04/2024 - 04/2017
5	Central Nervous System Neoplasms 12/2023 - 10/2007
5	Carcinogenesis 11/2022 - 03/2007
5	Edema (Dropsy) 10/2021 - 12/2010
4	Virus Diseases (Viral Diseases) 02/2023 - 10/2017

Drug/Important Bio-Agent (IBA)

95	Temozolomide (Temodar)FDA LinkGeneric 03/2024 - 03/2002
72	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2002
52	Biomarkers (Surrogate Marker)IBA 05/2024 - 12/2007
50	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 05/2024 - 10/2009
40	Bevacizumab (Avastin)FDA Link 01/2024 - 04/2010
39	DNA (Deoxyribonucleic Acid)IBA 05/2024 - 02/2006
33	Messenger RNA (mRNA)IBA 11/2022 - 05/2002
30	LigandsIBA 07/2022 - 01/2002
29	Alkylating AgentsIBA 05/2024 - 03/2005
27	MethyltransferasesIBA 05/2024 - 02/2006
26	Lomustine (CCNU)FDA Link 01/2024 - 05/2002
26	CytokinesIBA 01/2023 - 10/2003
21	ErbB Receptors (EGF Receptor)IBA 10/2021 - 01/2002
20	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 10/2004
20	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2021 - 08/2002
19	AntigensIBA 11/2023 - 05/2003
17	Transforming Growth Factor beta (TGF-beta)IBA 12/2016 - 10/2004
16	IntegrinsIBA 01/2024 - 12/2009
16	Immune Checkpoint InhibitorsIBA 01/2024 - 08/2015
15	CilengitideIBA 01/2024 - 12/2009
14	CaspasesIBA 04/2020 - 03/2002
13	O-(6)-methylguanineIBA 01/2024 - 02/2006
12	Phosphotransferases (Kinase)IBA 01/2023 - 11/2004
12	Vincristine (Oncovin)FDA LinkGeneric 07/2020 - 09/2002
12	O(6)-Methylguanine-DNA MethyltransferaseIBA 07/2014 - 09/2008
11	SteroidsIBA 04/2024 - 12/2010
11	Anticonvulsants (Antiepileptic Drugs)IBA 01/2023 - 08/2005
11	Procarbazine (Matulane)FDA Link 07/2020 - 10/2002
10	AntibodiesIBA 03/2019 - 01/2002
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 05/2002
9	Peptides (Polypeptides)IBA 01/2023 - 08/2002
9	Death Domain ReceptorsIBA 09/2013 - 01/2002
8	Angiogenesis InhibitorsIBA 11/2023 - 09/2010
8	Fas Ligand Protein (Fas Ligand)IBA 11/2022 - 01/2002
8	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2021 - 12/2010
8	MicroRNAs (MicroRNA)IBA 01/2020 - 08/2011
8	EnzymesIBA 01/2016 - 05/2005
7	VaccinesIBA 01/2023 - 01/2004
7	Monoclonal AntibodiesIBA 01/2023 - 10/2013
7	epidermal growth factor receptor VIIIIBA 12/2022 - 12/2012
7	InterferonsIBA 01/2022 - 09/2012
7	Neutralizing AntibodiesIBA 12/2019 - 11/2003
6	Amino Acids FDA Link 01/2024 - 01/2003
6	RNA (Ribonucleic Acid)IBA 01/2022 - 10/2006
6	Small Interfering RNA (siRNA)IBA 10/2017 - 10/2004
6	Methotrexate (Mexate)FDA LinkGeneric 09/2017 - 02/2002
6	HLA-G Antigens (HLA G)IBA 11/2005 - 05/2002
5	14- methyl- 20- oxa- 5,7,14,26- tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8(27),9,11,16,21,23- decaeneIBA 04/2024 - 01/2019
5	Cyclin-Dependent Kinases (cdk Proteins)IBA 12/2023 - 12/2009
5	depatuxizumab mafodotinIBA 01/2023 - 01/2020
5	Fibronectins (Fibronectin)IBA 03/2022 - 01/2013
5	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021 - 12/2013
5	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2020 - 01/2016
5	Protein Isoforms (Isoforms)IBA 01/2018 - 11/2013
5	AcidsIBA 06/2016 - 01/2005
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016 - 05/2013
5	CeramidesIBA 01/2013 - 09/2007
4	Histones (Histone)IBA 05/2024 - 08/2013
4	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2024 - 08/2007
4	Glutamic Acid (Glutamate)FDA Link 01/2024 - 07/2018
4	Chimeric Antigen ReceptorsIBA 11/2023 - 01/2018
4	Interferon Type IIBA 02/2023 - 12/2017
4	NivolumabIBA 01/2023 - 01/2017
4	ChromatinIBA 01/2023 - 05/2005
4	Levetiracetam (Keppra)FDA LinkGeneric 01/2022 - 02/2012

Therapy/Procedure

156	Therapeutics 05/2024 - 01/2002
119	Radiotherapy 05/2024 - 01/2002
117	Drug Therapy (Chemotherapy) 05/2024 - 09/2002
44	Immunotherapy 01/2024 - 12/2003
39	Chemoradiotherapy 03/2024 - 04/2003
7	Precision Medicine 12/2023 - 01/2010
6	Aftercare (After-Treatment) 10/2022 - 01/2012
5	Palliative Care (Palliative Therapy) 12/2020 - 09/2013